Therapeutic advances for Premature Ovarian Failure (POF)

15 April, 2021

Escrito por el equipo médico fivmadrid

Volver al blog

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the United States federal government agency for health, has published an inconclusive study that opens the possibility of reversing Premature Ovarian Failure (POF) with stem cells for the production of new eggs in the future.


Premature Ovarian Failure (POF) is an ovarian failure that occurs before the age of 40, and affects 1-5% of women. In this condition, the ovary does not produce sufficient amounts of estrogen and prevents the release of the mature egg in each menstrual cycle and therefore the possibility of pregnancy.


Among the most common symptoms of POF is the suspension and irregularity of menstrual cycles. As a consequence of the decrease in estrogen levels, signs similar to those of menopause may appear, among which are sudden flushing, difficulty sleeping, remembering or concentrating, vaginal dryness, depression, anxiety, and decreased sexual desire.


Premature Ovarian Failure can be caused by toxins released in radiation therapy or chemotherapy, pollution, pesticides, chemicals, or cigarette smoke.


Also due to genetic disorders, such as Mosaic Turner Syndrome and Fragile X Syndrome, as well as a family history of this disease. In addition, an autoimmune response against ovarian tissue, directly affecting follicles and ovules.


One of the main complications derived from POF is the inability to become pregnant naturally. In most cases, women with this pathology need egg donation to achieve pregnancy and carry it to term.


If you present any symptoms described above, you should go to an Assisted Reproduction specialist to evaluate your follicular reserve.


Call us if you have any questions. The online consultation is free and in FIVMadrid we will be happy to help and advise you.

Te ayudamos a resolver tus dudas